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  • Modeling pain score in clinical trials using a joint survival-longitudinal mixed model with a beta distribution in presence of missing values not occurring at random.

    Marion Bouillon-Pichault, Bruno Boulanger, Astrid Jullion, Bianca Teodorecu
     ARLENDA, Belgium

  • Pharmacokinetic design optimization in children and estimation of maturation parameters: example of cytochrome p450 3a4

    Marion BOUILLON-PICHAULT 1, 2, 3, 4, 5, Vincent JULLIEN 1, 2, 3, 4, Caroline BAZZOLI 6,
     Gérard PONS 1,2 ,3, 4, Michel TOD 7, 8, 9

    1. Université Paris Descartes, Paris, France;

    2. Inserm, U663, Paris, F-75015 France; University Paris Descartes, Faculty of Medicine, Paris, F-75005 France;

    3. RIPPS Network ;

    4. APHP, Groupe Hospitalier Cochin-Saint- Vincent de Paul , Paris, France;

    5. Arlenda, Belgium;

    6. INSERM, U738, Paris, France;

    7. Université de Lyon, Lyon, F-69003, France,

    8. Université Lyon 1, EA3738, CTO, Faculté de Médecine Lyon Sud, Oullins, F-69600, France. Pharmacie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

     

  • Validation de méthodes analytiques : recherche et dosage des stupéfiants dans le sang dans le cadre de la sécurité routière

    Validation de méthodes analytiques : Recherche et dosage des stupéfiants dans le sang dans le cadre de la sécurité routière O. ROUSSEL*, S. HERVE, P. HERARD, O.MESSINES, M. PERRIN

  • Use of accuracy profile for the validation of the direct quantitation of tagitinin c in tithonia diversifolia leaves by on-line coupling of supercritical co2 extraction to ft-ir spectroscopy by means of optical fibres

    E. Ziemons1, V. Barillaro2, E. Rozet1, N. Wandji Mbakop1, R. Lejeune1, L. Angenot3, L. Thunus1 and Ph. Hubert1

    1. Laboratory of Analytical Chemistry, Bioanalytical Chemistry Research Unit, Department of Pharmacy, University of Liège, Avenue de l’Hôpital 1,Bât B36, 4000 Liège, Belgium.
    2. Laboratory of Pharmaceutical Technology, Department of Pharmacy, University of Liège, Avenue de l’Hôpital 1, Bât B36, 4000 Liège, Belgium.
    3. Laboratory of Pharmacognosy, Department of Pharmacy, University of Liège, Avenue de l’Hôpital 1, Bât B36, 4000 Liège, Belgium.

  • Towards a risk based methodology to assess the acceptability of an analytical method transfer: comparison of different approaches.

    E. Rozet1, W. Dewe2, B. Govaerts3, B. Boulanger2, A. Ceccato2, P. Chiap4, J. Crommen4 and Ph. Hubert1

    1. Laboratory of Analytical Chemistry and 4 Laboratory of Analytical Pharmaceutical Chemistry, Bioanalytical Chemistry Research Unit, ULg, B 36, B-4000 Liège, Belgium.
    2. Lilly Development Centre, rue Granbompre, 11, B-1348 Mont-Saint-Guibert, Belgium.
    3. Institute of Statistics, Université Catholique de Louvain, 20, voie du Roman Pays, B-1348 Louvain-la-Neuve, Belgium.

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